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Research seeds: Psyllium husk

In this article, we discuss the “Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis” on ScienceDirect

Plant name and species

Psyllium husk (Plantago ovata)

Aim of study

This study investigates the effect of plantago ovata (PO) seeds on patients with ulcerative colitis who were in remission. They compared results with the pharmaceutical mesalamine which is used to treat various inflammatory bowel diseases.

Study method

Herbal preparation: Patients were given 10g of seeds twice a day.

Sample size: A total of 102 patients with ulcerative colitis who were in remission were randomly split into 3 groups. A total of 35 patients received PO, 37 received mesalamine and 30 received PO and mesalamine combined.

The three groups of patients were given either 10g of seeds twice a day, 500mg of mesalamine three times a day or PO seeds and mesalamine in the same doses. They were measuring for the maintenance of remission for 12 months.

Results of study

After 12 months, treatment success rate was 60% (21 of 35 patients) in the Plantago ovata seed group, 65% (24 of 37) in the mesalamine group, and 70% (21 of 30) in the Plantago ovata plus mesalamine group. 


The rationale for this study was that PO seeds yield butyrate in colonic fermentation (digestion in the colon). Butyrate enemas have shown promising effects for treating active distal ulcerative colitis, as they can stimulate mucosal repair.

This study shows that there was only 5% difference in efficacy between PO seeds and mesalamine. However, the sample sizes were small and so the difference is only marginal. The beneficial side of PO is that the side effects are relatively minimal, and not dangerous long term.

Side effects of mesalamine include joint and back pain and stiffness, vomiting, heartburn, itching, hair loss, and acne. More extreme potential side effects include blistering skin, mouth sores, flu-like symptoms, difficulty breathing or swallowing, blood in the stools and urine and extreme fatigue as well as many others. Therefore, it is arguable that to maximise quality of life and safety PO seeds may be a better option for many people.


Plantago ovata seeds (dietary fiber) might be as effective as mesalamine to maintain remission in ulcerative colitis.

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